High-Dose Vitamin C + Multi-Functional IV Therapy

What is Tokyo Relife's "Multi-Functional IV Therapy"?

Tokyo Relife Clinic's Multi-Functional IV Therapy is an advanced infusion treatment combining high-dose vitamin C with carefully selected medical-grade ingredients targeting four key concerns of modern life:

• Brain Function Fatigue
• Systemic Fatigue & Exhaustion
• Liver Function Support
• Skin Brightening & Care

Safety Protocol (G6PD Test)

Important Safety Measure: A G6PD deficiency test will be conducted based on physician assessment.

• This test is required only once in a lifetime.
• While some clinics may administer infusions without testing, medically, this is an absolute prerequisite to ensure the safety and efficacy of High-Dose Vitamin C therapy.
• Test results are available immediately.

At Tokyo Relife Clinic, patient safety is our absolute priority.

Why IV Achieves 70x Higher Bioavailability

Oral Limitation: Even with large oral doses of vitamin C supplements, intestinal absorption capacity has physiological limits, causing blood concentration to plateau.

IV Advantage: By administering 12.5-25g directly via intravenous infusion, research demonstrates blood concentration levels can reach over 70 times higher than oral supplementation※1.

Expected Benefits from Rapid Blood Concentration Increase:

• Antioxidant Action: Helps prevent cellular oxidation ("rusting") (*2)
• Collagen Synthesis Promotion: Builds the foundation for skin firmness and elasticity (*3)
• Neurotransmitter Synthesis Support: Helps regulate brain function and mood (*4)

Individual responses may vary. Mechanisms based on published pharmacological research, not guaranteed clinical outcomes.

Who Typically Considers This Treatment?

• Brain Fatigue: Declining focus and concentration
• Brain Fog and mental cloudiness
• Physical Fatigue and low energy levels
• Liver Stress: Frequent alcohol consumption or dining out
• Skin Concerns: UV damage or age-related loss of skin radiance

Customizable Treatment Options

You can select one, two, or all four targeted approaches based on your specific wellness priorities: (e.g., "lack of focus" or "liver burden from drinking").

1. Brain Function Support (Focus & Clarity)

Key Ingredient: Citicoline (CDP-Choline)※5
・Supports synthesis of acetylcholine, a neurotransmitter vital for memory and learning.

Note: Citicoline is approved in Japan for specific medical conditions; its use here for brain fatigue/focus support is an off-label self-pay treatment.

2. Fatigue Recovery (Energy Restoration)

Key Ingredient: Fursultiamine (Vitamin B1 Derivative)※6
・Supports fatigue management by reducing lactate levels
・Supports ATP (energy currency) production.

3. Liver Function Enhancement (For Frequent Drinkers)

Key Ingredients: Glycyrrhizin / Glutathione※7,8
・Supports hepatocytes (liver cells).
・Supports hepatic detoxification processes.
・Supports alcohol metabolism.

4. Skin Brightening Support (Radiance Care)

Key Ingredients: Tranexamic Acid / L-Cysteine※9,10
・Regulates melanin production processes.
・Supports normalization of skin turnover.

Synergistic Base Formula: In addition to High-Dose Vitamin C and these key ingredients, we include Vitamin B Complex as "essential vitamins" to support glucose metabolism and neurotransmitter synthesis, enhancing the synergistic effects of each component.

Note: Ingredient functions are based on pharmacological mechanisms and do not guarantee specific therapeutic outcomes.

Recommended Treatment Schedule: High-Dose Vitamin C Infusion

1. Comprehensive Wellness & Longevity Maintenance: 1-2 sessions per month

For routine oxidative stress management, skin metabolism support, and cellular-level anti-aging care, we recommend 1-2 monthly high-dose vitamin C sessions to maintain optimal baseline function.

2. Intensive Recovery & Enhanced Performance Care: Every 1-2 weeks

For severe fatigue, pre-event performance optimization, or accelerated skin improvement, more frequent sessions maintain elevated vitamin C blood concentrations, supporting rapid recovery when peak performance is essential.

※ Personalized Plans: Treatment schedules are customized by our physicians based on your medical assessment and lifestyle factors.

Procedure Guide: High-Dose Vitamin C

1. Medical Questionnaire & Consultation (~10 min)

Complete a health questionnaire (medical history, allergies) while our nurse assesses your current concerns and expectations.

2. Physician Examination & Consent Form (~20 min)

Consult with our physician to determine:
・Vitamin C dosage: 12.5g or 25g
・Selection from the 4 treatment options
・G6PD testing requirement (results available immediately)
・Signing of consent forms

3. Payment (~10 min)

Payment is processed while your IV formulation is prepared.

4. High-Dose Vitamin C Infusion (~45-60 min)

Infusion speed may be adjusted if vascular pain occurs. First-time patients receiving 25g should allow extra time.

Precautions for High-Dose Vitamin C

Contraindications (Who Cannot Receive High-Dose Vitamin C)

Absolute Contraindications:
・Individuals under 18 years of age
・Pregnant, breastfeeding, or potentially pregnant women
・Patients on dialysis or with renal insufficiency
・Severe cardiac failure
・Severe ascites or edema
・Primary hyperoxaluria
・G6PD Deficiency
Note: Final eligibility is determined by our physician.

Precautions (Requiring Careful Evaluation)

・History of infectious diseases, diabetes, dehydration, or urinary stones
・Current use of medications for the above conditions
・Oral Contraceptives: Patients taking birth control pills may not be eligible for Tranexamic Acid due to thrombosis risk.
・Empty Stomach: Please eat before arrival to prevent hypoglycemia.
Treatment may be declined based on severity of condition. Physician's decision is final.

Important Regulatory & Safety Notices

Japanese Pharmaceutical Affairs Law:
・Domestic Approval: All ingredients are approved in Japan, but their use for specific purposes (e.g., "Brain Fog") falls under off-label self-pay medical care.

International Safety Information:
・G6PD Deficiency Risk: Administering high-dose Vitamin C to G6PD-deficient patients can cause hemolytic anemia (red blood cell destruction). Therefore, G6PD testing is mandatory at our clinic prior to administration to ensure safety.

Frequently Asked Questions (FAQ)

Q: Who typically considers high-dose vitamin C IV therapy?
A: This treatment is often chosen by individuals experiencing:
　・Brain fog and declining concentration
　・Persistent fatigue and low energy
　・Frequent alcohol consumption (liver support needs)
　・UV damage and skin dullness concerns

Q: How quickly can changes be noticed?
A: Brain function and energy restoration: Most patients report experiencing "mental clarity improvement" or "reduced fatigue sensation" within 24-48 hours following treatment.
Skin radiance enhancement: Visible improvements typically become apparent after 4-6 weeks of consistent treatment, corresponding with natural skin cell renewal cycles.
Individual response patterns vary significantly based on physiological factors and lifestyle variables.

Q: How often should I receive treatment? 

A. Recommended intervals vary by treatment goals:

• Routine Maintenance & Comprehensive Care: 1-2 times per month
• Intensive Fatigue Recovery & Focused Care: Every 1-2 weeks

※ These intervals are general guidelines. Actual treatment plans are customized by physicians based on individual medical assessment.

Q: What is the duration of each treatment session?
A: Infusion administration: 45-60 minutes
Complete first-visit duration: Approximately 90 minutes (includes consultation, G6PD testing when required, and treatment administration)
High-dose Vitamin C has high osmotic pressure, which may cause vascular pain; infusion speed will be lowered in such cases, extending the time. Please allow ample time.

Q: Is the infusion process uncomfortable?
A: There is a slight prick during needle insertion. Due to high osmotic pressure, some patients feel vascular pain in the arm. We manage this by adjusting the drip speed. Please inform staff immediately if you feel discomfort.

Q: Are there side effects?
A: Generally safe, but potential reactions include:
　・Vascular pain (managed by speed adjustment)
　・Hypoglycemia symptoms (if fasting or diabetic)
　・Rare headache/nausea
　・Subcutaneous bruising at injection site
Serious risk: Hemolytic anemia in G6PD-deficient patients (prevented by our mandatory testing).

Q: Other clinics didn't require G6PD testing. Why do you?
A: Medically safe high-dose vitamin C requires G6PD status confirmation. Facilities omitting this test may be:
　・Using lower concentrations to reduce liability
　・Prioritizing convenience over safety protocols
Tokyo Relife Clinic follows evidence-based international safety standards. G6PD deficiency can cause life-threatening hemolytic anemia at therapeutic concentrations.

Q: What is Citicoline?
A: Citicoline (CDP-Choline) is a pharmaceutical-grade cognitive enhancement compound that promotes acetylcholine synthesis in brain tissue. Extensively utilized in European and North American medical practices for brain fog and cognitive optimization.
Clinical Note: Very few Tokyo facilities offer IV citicoline, making this a unique therapeutic option.

Q: Can anyone receive treatment?
A: No. Minors (<18), pregnant/breastfeeding women, and dialysis patients cannot receive it. Patients on oral contraceptives cannot receive Tranexamic Acid formulations due to clot risk. Physician determination is final.

Q: Any preparations for the day?
A: Please eat before coming. Fasting increases the risk of hypoglycemia-like symptoms during high-dose infusion.

Q: Is G6PD testing needed every time?
A: No. G6PD deficiency is genetic. Once confirmed negative, you never need to test again for your lifetime. We require it only for patients with no proof of prior testing.

Resources:

※1　Padayatty SJ, et al. Ann Intern Med. 2004;140(7).
※2　Chen Q, et al. Proc Natl Acad Sci U S A. 2005;102(38).
※3　Cosgrove MC, et al. Am J Clin Nutr. 2007;86(4).
※4　Harrison FE, May JM. Free Radic Biol Med. 2009;46(6).
※5　Secades JJ. Rev Neurol. 2016;62(8):355-62
※6　Nozaki S, et al. Nutr Res. 2009;29(12).
※7　Manns MP, et al. Lancet. 2003;362(9387).
※8　Lee YJ, et al. Clin Nutr Res. 2024;13(3).
※9　Tse TW, et al. J Cosmet Dermatol. 2013;12(1).
※10　Sato Y, et al. Cosmetics. 2023;10(3).

Research Disclaimer: Referenced studies include small-scale clinical trials and basic research. Individual therapeutic outcomes are not guaranteed and response patterns vary significantly between patients.